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Bencelin Combo 1,200,000U INJ SOL 3ml 1 AMP, Benzathine, Benzlypenicin

Bencelin Combo 1,200,000U INJ SOL 3ml 1 AMP, Benzathine, Benzlypenicin
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Bencelin Combo 1,200,000U INJ SOL 3ml , Benzathine, Benzlypenicillin

INDICATIONS: Prophylaxis of rheumatic fever and carriers of beta-hemolytic streptococcus, rheumatic heart disease, glomerulonephritis, recurrent tonsillitis, syphilis in its various stages.

Pharmacokinetics HUMAN benzathine benzylpenicillin exerts its bactericidal activity by inhibiting bacterial cell wall synthesis.

It is very active against streptococci of groups A, C, G, H, L, M, pneumococci, Neisseria gonorrhoeae, Bacillus anthracis, Actinomyces bovis, Clostridium, Streptobacillus moniliform, Leptospira, Listeria monocytogenes and Treponema pallidum which is very sensitive to action of penicillin G benzathine, not active against penicillinase-producing bacteria.

Penicillin G benzathine, BENCELIN * is acting as it keeps prolonged therapeutic serum levels. Is administered intramuscularly slowly absorbed, providing a constant level over a long period.

Their maximum serum concentration observed in the first 24 hours after application, persisting until 4 weeks, depending on the dose.

Approximately 60% of penicillin binds to plasma proteins, is distributed in all tissues in varying amounts.

The highest concentrations are found in kidney, and are lower in liver, skin and intestine, penetrates to a lesser extent in other tissues and in cerebrospinal fluid, and is almost completely eliminated by the kidneys.

CONTRAINDICATIONS: Do not administer to patients with history of allergy to penicillin or infections resistant germs, must not be used near a nerve or artery.

Special Precautions: Penicillin should be used with caution in individuals with a history of allergy to cephalosporins especially in those who have asthma. The use of any antibiotic, especially in large doses and for prolonged periods can result in overgrowth of nonsusceptible organisms, making it necessary to frequently check the patients.

Whenever allergic reactions occur, penicillin was discontinued at the discretion of the physician, who shall institute the correct treatment of the same.

In streptococcal infections, treatment should eradicate the organism, otherwise there could be sequelae of streptococcal disease, so they should make the crop takes a timely manner after completing the antibiotic treatment.

RESTRICTIONS OF USE DURING PREGNANCY AND BREASTFEEDING BENCELIN * can be used during pregnancy and lactation only if there is an indication for their use and after having assessed the risk-benefit, because it crosses the placenta and is excreted milk.

ADVERSE REACTIONS: Penicillin is a drug with very low toxicity, however, has a significant degree of sensitivity whose reactions may range from urticaria to anaphylaxis.

Other infrequent reactions related to high doses can be: Hemolytic anemia, leukopenia, thrombocytopenia, neuropathy and nephropathy.

During treatment for syphilis have been reported cases of Jarisch-Herxheimer.

DRUG INTERACTIONS AND OTHER GENDER: Aspirin and phenylbutazone increase the effect of penicillin decrease the plasma protein binding.

The effect of penicillin is decreased when administered with erythromycin, chloramphenicol, tetracycline or neomycin.

Probenecid increases from 3 to 5 times the blood level of penicillin, because it inhibits the tubular active transport mechanism thereof.

Penicillin can increase the power of anticoagulants.

CHANGES IN RESULTS OF LABORATORY TESTS determinations of urine glucose tests when performed by the method of Fehling (copper sulfate) may give false-positive results.

PRECAUTIONS IN RELATION TO EFFECTS Carcinogenesis, Mutagenesis, Impairment of Fertility: Although penicillin crosses the placenta, no effects have been reported mutagenesis or teratogenesis, no effects have been reported carcinogenicity or fertility.


In adults for prophylaxis of hemolytic streptococcal infections in patients with rheumatic fever: 1'200, 000 IU every 3 weeks.

Where primary, secondary, or latent: A single application of 2.4 million units.

In case of late syphilis or neurosyphilis: 2.4 million units every 7 days repeated application 2 more times for a total of 7.2 million units of penicillin.

MANIFESTATIONS AND MANAGEMENT OF OVERDOSE OR ACCIDENTAL INGESTION: Because it has a high therapeutic index, no cases of overdose reported to date.

Usually, the penicillins are minimal direct toxicity to man. However, the viscous nature of the suspension of benzathine penicillin may cause any of the neurovascular effects for which treatment should be symptomatic and supportive. No reported cases of overdosage with BENCELIN *.

In case of mild or moderate allergic controlled with antihistamines, if necessary corticosteroids are used parenterally. Anaphylactic reactions are emergency medicine, immediate treatment is required, preferably in a hospital setting, and the administration of epinephrine 1:1,000, theophylline, intravenous corticosteroids and supportive measures such as control of the airway, if necessary intubando and oxygen administration.

PRESENTATION: Box with vial with 1'200, 000 IU vial with 5 mL of diluent.
Drug Name: Bencelin combinado
Comparable patent medicine: Benzetacil
Active substance: Benzathine benzylpenicillin
Presentation: Injectable Sun
Concentration: 1,200,000 U
Prolonged release tablets: No
Laboratory: AMSA, Inc. de CV
Box with vial with powder and vial
With diluent 5ml
Made in Mexico

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